ANALYTICAL METHOD VALIDATION FOR THE IDENTIFICATION AND QUANTIFICATION OF DISSOLVED GOLD AND GOLD NANOPARTICLES IN COSMETICS PRODUCTS BY SINGLE PARTICLE INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY

Nanoparticle (NP) applications have recently gained more space in the development of many products, especially cosmetology. The aim present study was to validate a single particle inductively coupled plasma mass spectrometry technique for detection and quantification gold nanoparticles (AuNPs) ions (Au (i)) different cosmetics currently marketed Brazil. size limit pure AuNPs 22 nm, concentration 2.3×106 particles g?1 achieved. total 0.02 µg L?1 obtained standard mode conditions. recovery achieved 98% dissolved Au 109% AuNPs; relative deviation <5%. This validated method applied cosmetic products (n = 10) from national international industrial producers. Most analysed contained quantifiable amounts (< 0.005-2.1 g?1) only four variability results detected LOD – 9.3 × 108 g?1). that greatest amount these metallic NPs were artisanal products. demonstrate importance adequate quality control ensure consumer safety